RegisterLogin

CD8B Antibody

CAT: 247-OAEE00998-100UGSize: 0.1 mg (C100)Dry Ice: NoHazardous: No
0.1 mg (C100)Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
9007-83-4
Gene Name
CD8b molecule
Gene Aliases
CD8 antigen, beta polypeptide 1 (p37) ; CD8B1; LEU2; LY3; LYT3; P37; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain.
Gene ID
926
Accession Number
NP_001171571.1NP_004922.1NP_742099.1NP_742100.1NP_757362.1
Reactivity
Rat
Immunogen
CD8 positive Wistar rat splenic T cell hybridomas
Target
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs) . In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs) . Additionally, plays a critical role in thymic selection of CD8+ T-cells.
Clonality
Monoclonal
Clone
341
Conjugation
FITC
Type
Monoclonal Antibody
Applications
Flow cytometry
Purification
Purified by size-exclusion chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Buffer
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
The mouse monoclonal antibody 341 (also known as 34.1) recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor, expressed on T cell subsets and some other cell types, such as macrophages.
NCBI Gene Symbol
CD8B
Host or Source
Mouse
Protein Name
T-cell surface glycoprotein CD8 beta chain
Gene Name URL
CD8B
Nucleotide Accession Number
NM_001178100.1NM_004931.4NM_172101.3NM_172102.3NM_172213.3

Related Products

CatalogName
OPCD02047-10UGCD8B Recombinant Protein
OPCD02047-200UGCD8B Recombinant Protein
OPCD02047-50UGCD8B Recombinant Protein
OCOA20953-20UGCD8B Protein Lysate
OPCD02048-50UGCD8B Recombinant Protein
OPCD02049-200UGCD8B Recombinant Protein
OPCD02049-10UGCD8B Recombinant Protein
AAP42204-100UGCD8B Peptide (AAP42204)
OPCD02048-10UGCD8B Recombinant Protein
OCOA05216-20UGCD8B Protein Lysate

Alternative Products

CatalogName
MBS8504169-01CD8B Antibody
MBS8511769-01CD8B Antibody
V8881-100UGCD8B Antibody
AF5138-01CD8B Antibody
MBS5309222-01CD8b antibody
FNab01506CD8B antibody
E93286CD8B Antibody
GWB-8D516BCD8B Antibody
10R-CD8baCKpCD8b antibody
ABF5138CD8B Antibody

Popular Products