Products for Research Use Only
RegisterLogin

STAT1 Antibody

CAT: 0247-OAEE00535-100UGSize: 0.1 mg (C100)Dry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OAEE00535-100UGSize:0.1 mg (C100)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Name
Signal transducer and activator of transcription 1
Gene Aliases
CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; STAT91; transcription factor ISGF-3 components p91/p84.
Gene ID
6772
Accession Number
NP_009330.1NP_644671.1XP_006712781.1
Reactivity
Human|Mouse
Immunogen
STAT1 peptide sequence 721-733 (DNLLPMSPEEFDE) .
Target
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426) . ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788) . It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Clonality
Monoclonal
Clone
SM1
Type
Monoclonal Antibody
Applications
Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution
2°C to 8°C
Molecular Weight
91 kDa
Fragment
IgG2b
Specificity
The antibody SM1 recognizes an epitope included within amino acids 721-733 of STAT1, a 91 kDa transcriptional factor involved in a variety of systems including antiviral responses and interferon alpha (IFN-alpha) and gamma (IFN-gamma) signal transduction.
NCBI Gene Symbol
STAT1
Host or Source
Mouse
Protein Name
Signal transducer and activator of transcription 1-alpha/beta
Gene Name URL
STAT1
Nucleotide Accession Number
NM_007315.3NM_139266.2XM_006712718.1

Related Products

CatalogName
OPPA01173-2UGSTAT1 Protein
OPCD07218-50UGSTAT1 Recombinant Protein
AAP36979-100UGSTAT1 Peptide (AAP36979)
AAP38934-100UGSTAT1 Peptide (AAP38934)
OPCD07217-50UGSTAT1 Recombinant Protein
AAP33374-100UGSTAT1 Peptide (AAP33374)
OCOA06310-20UGSTAT1 Protein Lysate
OCOA19651-20UGSTAT1 Protein Lysate
OCOA11693-20UGSTAT1 Protein Lysate
AAP38933-100UGSTAT1 Peptide (AAP38933)

Alternative Products

CatalogName
70R-50429STAT1 antibody

Popular Products