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GZMB Antibody

CAT: 0247-OAEE00403-100UGSize: 0.1 mg (C100)Dry Ice: NoHazardous: No
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CAT#:0247-OAEE00403-100UGSize:0.1 mg (C100)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Granzyme B
Gene Aliases
C11; cathepsin G-like 1; CCPI; CGL1; CGL-1; CSPB; CSP-B; CTLA1; CTLA-1; CTSGL1; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2; fragmentin 2; Fragmentin-2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) ; Granzyme-2; HLP; human lymphocyte protein; SECT; T-cell serine protease 1-3E.
Gene ID
3002
Accession Number
NP_004122.2
Reactivity
Human|Non-human Primate
Immunogen
Human NK cell line YT-INDY-derived granzyme B
Target
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Clonality
Monoclonal
Clone
CLB-GB11
Type
Monoclonal Antibody
Applications
Flow cytometry
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Buffer
Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed in activated Tc cells and NK cells.
NCBI Gene Symbol
GZMB
Host or Source
Mouse
Protein Name
Granzyme B
Gene Name URL
GZMB
Nucleotide Accession Number
NM_004131.4

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