CD4 Antibody

CAT: 0247-OAEE00229-100UGSize: 0.1 mg (C100)Dry Ice: NoHazardous: No
CAT#:0247-OAEE00229-100UGSize:0.1 mg (C100)
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CAS Number
9007-83-4
Gene Name
CD4 antigen
Gene Aliases
L3T; L3T4; Ly-; Ly-4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4.
Gene ID
12504
Accession Number
NP_000607.1
Reactivity
Mouse
Immunogen
Mouse CTL clone V4 cells
Target
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs) . In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Clonality
Monoclonal
Clone
GK1.5
Type
Monoclonal Antibody
Applications
Flow cytometry|Functional assay|Immunocytochemistry|Immunohistochemistry-Frozen|Immunoprecipitation
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4
Buffer
Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized.
Reconstitution
2°C to 8°C
Fragment
IgG2b
Specificity
The rat monoclonal antibody GK1.5 reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa) .
NCBI Gene Symbol
Cd4
Host or Source
Rat
Protein Name
T-cell surface glycoprotein CD4
Gene Name URL
Cd4
Nucleotide Accession Number
NM_000616.4

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