CD300A Antibody

• Gene Name:

  CD300a molecule

• Gene Aliases:

  CD300 antigen-like family member A; CD300a antigen; CLM-8; CMRF35H; CMRF35-H; CMRF-35H; CMRF35H leukocyte immunoglobulin-like receptor; CMRF35H9; CMRF35-H9; CMRF-35-H9; CMRF35-like molecule 8; IGSF12; immunoglobulin superfamily member 12; inhibitory receptor protein 60; IRC1; IRC1/IRC2; IRC2; IRp60; leukocyte membrane antigen; NK inhibitory receptor.

• Gene ID:

  11314

• Accession Number:

  NP_001243770.1NP_009192.2

• Reactivity:

  Human

• Immunogen:

  HPB human acute lymphoid leukemia cell line

• Target:

  Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027) . Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923) .

• Clonality:

  Monoclonal

• Clone:

  MEM-260

• Type:

  Monoclonal Antibody

• Applications:

  Flow cytometry|Western blot

• Purification:

  Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• Buffer:

  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

• Reconstitution:

  2°C to 8°C

• Fragment:

  IgG1

• Specificity:

  The antibody MEM-260 reacts with CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells.

• NCBI Gene Symbol:

  CD300A

• Host or Source:

  Mouse

• Protein Name:

  CMRF35-like molecule 8

• Gene Name URL:

  CD300A

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001256841.1NM_007261.3