CD11b antibody

• Gene Name :

  Integrin subunit alpha M

• Gene Aliases :

  Antigen CD11b (p170) ; CD11 antigen-like family member B; CD11B; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit) ; leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; macrophage-1 antigen alpha subunit; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6.

• Gene ID :

  3684

• Accession Number :

  NP_000623.2NP_001139280.1

• Reactivity :

  Human

• Immunogen :

  Human granulocytes

• Target :

  Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980) . In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407) . May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity) . May play a role in mast cell development (By similarity) .

• Clonality :

  Monoclonal

• Clone :

  MEM-174

• Type :

  Monoclonal Antibody

• Applications :

  Flow cytometry|Immunoprecipitation

• Purification :

  Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1 mg/ml

• Format :

  Phosphate buffered saline (PBS), pH 7.4

• Buffer :

  Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized.

• Reconstitution :

  2°C to 8°C

• Fragment :

  IgG2a

• Specificity :

  HLDA VI; WS Code BP 310// HLDA VI; WS Code M 18//HLDA VI; WS Code M 18//

• NCBI Gene Symbol :

  ITGAM

• Host or Source :

  Mouse

• Protein Name :

  Integrin alpha-M

• Gene Name URL :

  ITGAM

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_000632.3NM_001145808.1