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CD95 Antibody

CAT: 0247-OADB00269-200ULSize: 200 µLDry Ice: NoHazardous: No
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CAT#:0247-OADB00269-200ULSize:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Fas cell surface death receptor
Gene Aliases
APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6
Gene ID
355
Accession Number
NP_000034.1
Reactivity
Human
Target
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD) . The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Clonality
Monoclonal
Clone
B-G27
Type
Monoclonal Antibody
Applications
FC, IHC-F
Purification
Ion exchange chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 ug/uL
Bioactivity
Triggers apoptotic cell death
Format
Liquid
Buffer
Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free
Reconstitution
Stable at +2-8C for 12 months. For longer storage, freeze aliquots
Molecular Weight
38 kDa
Fragment
Mouse IgG2a
Specificity
Recognises the Fas, APO1 antigen, a 45 kDa protein
NCBI Gene Symbol
CD95
Host or Source
Human
Protein Name
Tumor necrosis factor receptor superfamily member 6
Gene Name URL
CD95
Nucleotide Accession Number
NM_000043.4

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