CD130 Antibody

• Gene Name:

  Interleukin 6 signal transducer

• Gene Aliases:

  CD130, GP130, HIES4, CDW130, IL-6RB, sGP130

• Gene ID:

  3572

• Accession Number:

  NP_001177910.1

• Reactivity:

  Human

• Target:

  The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM) . This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.

• Clonality:

  Monoclonal

• Clone:

  B-R3

• Type:

  Monoclonal Antibody

• Applications:

  FC

• Purification:

  Ion exchange chromatography

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 ug/uL

• Format:

  Lyophilized

• Buffer:

  Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free

• Reconstitution:

  Stable at +2-8C for 12 months. For longer storage, freeze aliquots

• Molecular Weight:

  104 kDa

• Fragment:

  IgG2a

• Specificity:

  Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein

• NCBI Gene Symbol:

  CD130

• Host or Source:

  Mouse

• Protein Name:

  Interleukin-6 receptor subunit beta

• Gene Name URL:

  CD130

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001190981.1