CD126 Antibody

• Gene Name:

  Interleukin 6 receptor

• Gene Aliases:

  IL6Q, gp80, CD126, HIES5, IL-6R, IL6RA, IL6RQ, IL-1Ra, IL-6RA, IL6QTL, IL-6R-1

• Gene ID:

  3570

• Accession Number:

  NP_000556.1

• Reactivity:

  Human

• Target:

  This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

• Clonality:

  Monoclonal

• Clone:

  B-R6

• Type:

  Monoclonal Antibody

• Applications:

  FC, IHC-F

• Purification:

  Ion exchange chromatography

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  200 tests/2mL

• Bioactivity:

  Recognises both soluble and membrane bound IL-6 R

• Format:

  Lyophilized

• Buffer:

  Phosphate-buffered saline with 1 % BSA and 0.1 % sodium azide

• Reconstitution:

  Stable at +2-8C for 12 months. For longer storage, freeze aliquots

• Molecular Weight:

  52 kDa

• Fragment:

  IgG1

• Specificity:

  Recognises the Interleukin-6 Receptor α subunit, IL-6 Ra, IL-6 R, a 80 kDa protein

• NCBI Gene Symbol:

  CD126

• Host or Source:

  Mouse

• Protein Name:

  Interleukin-6 receptor subunit alpha

• Gene Name URL:

  CD126

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_000565.3