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CD126 Antibody

CAT: 0247-OADB00036-200UGSize: 200 µgDry Ice: NoHazardous: No
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CAT#:0247-OADB00036-200UGSize:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Interleukin 6 receptor
Gene Aliases
IL6Q, gp80, CD126, HIES5, IL-6R, IL6RA, IL6RQ, IL-1Ra, IL-6RA, IL6QTL, IL-6R-1
Gene ID
3570
Accession Number
NP_000556.1
Reactivity
Human
Target
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Clonality
Monoclonal
Clone
B-F19
Type
Monoclonal Antibody
Applications
FC
Purification
Ion exchange chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 ug/uL
Bioactivity
Blocks IL-6 induced proliferation of XG-1 cell line, Blocks IL-6 binding to its receptor, Recognises both soluble and membrane bound IL-6 R
Format
Lyophilized
Buffer
Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free
Reconstitution
Stable at +2-8C for 12 months. For longer storage, freeze aliquots
Molecular Weight
52 kDa
Fragment
IgG1
Specificity
Recognises the Interleukin-6 Receptor α subunit, IL-6 Ra, IL-6 R, a 80 kDa protein
NCBI Gene Symbol
CD126
Host or Source
Mouse
Protein Name
Interleukin-6 receptor subunit alpha
Gene Name URL
CD126
Nucleotide Accession Number
NM_000565.3

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