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SMAD6 Antibody

CAT: 0247-OACD07381-1MLSize: 1 mLDry Ice: NoHazardous: No
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CAT#:0247-OACD07381-1MLSize:1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
SMAD family member 6
Gene Aliases
AOVD2; HsT17432; MAD homolog 6; MADH6; MADH7; mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; SMAD family member 6; SMAD, mothers against DPP homolog 6.
Gene ID
4091
Accession Number
NP_005576.3
Reactivity
Human|Mouse|Rat
Immunogen
Range: Cys261 - Pro495
Target
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
26 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against Smad6. It has been selected for its ability to recognize Smad6 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
SMAD6
Host or Source
Rabbit
Protein Name
Mothers against decapentaplegic homolog 6
Gene Name URL
SMAD6
Nucleotide Accession Number
NM_005585

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