PTPRN Antibody

CAT: 0247-OACD06840-1MLSize: 1 mLDry Ice: NoHazardous: No
CAT#:0247-OACD06840-1MLSize:1 mL
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CAS Number
9007-83-4
Gene Name
Protein tyrosine phosphatase receptor type N
Gene Aliases
IA2; IA-2; IA-2/PTP; ICA 512; ICA512; insulinoma-associated tyrosine-phosphatase-like protein; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; PTP IA-2; receptor-type tyrosine-protein phosphatase-like N; R-PTP-N.
Gene ID
5798
Accession Number
NP_001186692.1
Reactivity
Human|Porcine|Rat
Immunogen
Range: Val35 - Leu185
Target
Plays a role in vesicle-mediated secretory processes (PubMed:24843546) . Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity) . Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546) . Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546) . Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity) . In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity) . Required to maintain normal levels of renin expression and renin release (By similarity) . Seems to lack intrinsic enzyme activity (By similarity) . May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
96 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PTPRN. It has been selected for its ability to recognize PTPRN in immunohistochemical staining and western blotting.
NCBI Gene Symbol
PTPRN
Host or Source
Rabbit
Protein Name
Receptor-type tyrosine-protein phosphatase-like N
Gene Name URL
PTPRN
Nucleotide Accession Number
NM_001199763

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