PTPRH Antibody

CAT: 0247-OACD06833-1MLSize: 1 mLDry Ice: NoHazardous: No
CAT#:0247-OACD06833-1MLSize:1 mL
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CAS Number
9007-83-4
Gene Name
Protein tyrosine phosphatase, receptor type, H
Gene Aliases
Receptor type protein tyrosine phosphatase sap-1; receptor-type tyrosine-protein phosphatase H; R-PTP-H; SA; sap-1; stomach cancer-associated protein tyrosine phosphatase 1.
Gene ID
545902
Accession Number
NP_997153.2
Reactivity
Mouse
Immunogen
Range: Gln685 - Ser909
Target
Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of Jurkat cells (By similarity) . Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response (PubMed:26195794) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunohistochemistry|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
107 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PTPRH. It has been selected for its ability to recognize PTPRH in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Ptprh
Host or Source
Rabbit
Protein Name
Receptor-type tyrosine-protein phosphatase H
Gene Name URL
Ptprh
Nucleotide Accession Number
NM_207270

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