PKN2 Antibody

CAT: 0247-OACD06546-1MLSize: 1 mLDry Ice: NoHazardous: No
CAT#:0247-OACD06546-1MLSize:1 mL
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CAS Number
9007-83-4
Gene Name
Protein kinase N2
Gene Aliases
6030436C20Rik; AI507382; PKN gamma; PR; Prk; PRK2; Prkcl2; protein kinase C-like 2; protein-kinase C-related kinase 2; serine/threonine kinase 7; serine/threonine-protein kinase N2; Stk; Stk7.
Gene ID
109333
Accession Number
NP_848769.2
Reactivity
Human|Mouse|Rat
Immunogen
Range: Leu282 - Lys487
Target
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF) . Involved in the negative regulation of ciliogenesis (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
89 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PKN2. It has been selected for its ability to recognize PKN2 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Pkn2
Host or Source
Rabbit
Protein Name
Serine/threonine-protein kinase N2
Gene Name URL
Pkn2
Nucleotide Accession Number
NM_178654

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