PAPPA Antibody

CAT: 0247-OACD06290-1MLSize: 1 mLDry Ice: NoHazardous: No
CAT#:0247-OACD06290-1MLSize:1 mL
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CAS Number
9007-83-4
Gene Name
Pregnancy-associated plasma protein A
Gene Aliases
8430414N03Rik; IGFBP-; IGFBP-4ase; IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; P; PA; PAG1; PAPP-A; pappalysin-1; Pregnancy-associated plasma protein A.
Gene ID
18491
Accession Number
NP_067337.1
Reactivity
Human|Mouse|Rat
Immunogen
Range: Phe999 - Asn1272
Target
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
181 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PAPPA. It has been selected for its ability to recognize PAPPA in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Pappa
Host or Source
Rabbit
Protein Name
Pappalysin-1
Gene Name URL
Pappa
Nucleotide Accession Number
NM_021362

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