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OAS1A Antibody

CAT: 0247-OACD06185-1MLSize: 1 mLDry Ice: NoHazardous: No
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CAT#:0247-OACD06185-1MLSize:1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
2'-5' oligoadenylate synthetase 1A
Gene Aliases
(2-5') oligo (A) synthase 1; (2-5') oligo (A) synthase 1A; (2-5') oligo (A) synthetase 1;2',5'-oligoadenylate synthetase 1, 40/46kDa;25 oligoadenylate synthetase;2'-5' oligoadenylate synthetase 1G;2-5A synthase 1;2-5A synthase 1A;2-5A synthetase 1;2'-5'-oligoadenylate synthase 1;2'-5'-oligoadenylate synthase 1A;2'-5'-oligoadenylate synthetase 1; Oas1; Oas1g.
Gene ID
192281
Accession Number
NP_620268.1
Reactivity
Rat
Immunogen
Range: Ala139 - Leu358
Target
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
42 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against OAS1. It has been selected for its ability to recognize OAS1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Oas1a
Host or Source
Rabbit
Protein Name
2'-5'-oligoadenylate synthase 1A
Gene Name URL
Oas1a
Nucleotide Accession Number
NM_138913

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