NOTCH2 Antibody

• Gene Name :

  Notch receptor 2

• Gene Aliases :

  AGS2; HJCYS; hN2; neurogenic locus notch homolog protein 2; notch 2; Notch homolog 2.

• Gene ID :

  4853

• Accession Number :

  NP_001186930.1

• Reactivity :

  Human|Porcine|Rat

• Immunogen :

  Recombinant NOTCH2 (Ala2251 - Asn2466) expressed in E.coli

• Target :

  Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) . Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593) . Positively regulates self-renewal of liver cancer cells (PubMed:25985737) .

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Applications :

  Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunohistochemistry|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot

• Purification :

  Affinity Purified; Protein A Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  0.5 mg/ml

• Format :

  Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

• Reconstitution :

  2°C to 8°C|-20°C

• Specificity :

  The antibody is a rabbit polyclonal antibody raised against NOTCH2. It has been selected for its ability to recognize NOTCH2 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol :

  NOTCH2

• Host or Source :

  Rabbit

• Protein Name :

  Neurogenic locus notch homolog protein 2

• Gene Name URL :

  NOTCH2

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001200001