RegisterLogin

MAP2K1 Antibody

CAT: 0247-OACD05415-100ULSize: 100 µLDry Ice: NoHazardous: No
CAT#:0247-OACD05415-100ULSize:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
9007-83-4
Gene Name
Mitogen-activated protein kinase kinase 1
Gene Aliases
CFC3; dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEK1; MEL; MKK1; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) .
Gene ID
5604
Accession Number
NP_002746.1
Reactivity
Human|Mouse|Porcine|Rat
Immunogen
Range: Leu54 - Val369
Target
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
41 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against MAP2K1. It has been selected for its ability to recognize MAP2K1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
MAP2K1
Host or Source
Rabbit
Protein Name
Dual specificity mitogen-activated protein kinase kinase 1
Gene Name URL
MAP2K1
Nucleotide Accession Number
NM_002755

Related Products

CatalogName
OAAQ00166-20ULHuman MAP2K1/MAP2K2 Antibody (Phospho-Ser221)
OAAQ00166-200ULHuman MAP2K1/MAP2K2 Antibody (Phospho-Ser221)
OAOA22192-50UGMAP2K1 Detection Antibody
OAOA21734-100UGMAP2K1 Capture Antibody
OABB00334-100UGMAP2K1 Polyclonal Antibody
OAOA21738-100UGMAP2K1 Capture Antibody
OAOA21737-100UGMAP2K1 Capture Antibody
OAOA21736-100UGMAP2K1 Capture Antibody
OAOA21741-100UGMAP2K1 Capture Antibody
OAOA21740-100UGMAP2K1 Capture Antibody

Alternative Products

CatalogName
MBS7123949-01MAP2K1 Antibody

Popular Products