LYAR Antibody

• Gene Name:

  Ly1 antibody reactive clone

• Gene Aliases:

  Cell growth-regulating nucleolar protein; ly1 antibody-reactive protein; MLZ-264; protein expressed in male leptotene and zygotene spermatocytes 264.

• Gene ID:

  17089

• Accession Number:

  NP_079557.2

• Reactivity:

  Human|Mouse|Rat

• Immunogen:

  Range: Gly270 - Lys388

• Target:

  Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity) . Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity) . Represses the expression of embryonic globin Hbb-y gene (PubMed:25092918) . In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity) . Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity) . Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (PubMed:25735755) . Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080) .

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

• Purification:

  Affinity Purified; Protein A Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Format:

  Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

• Reconstitution:

  2°C to 8°C|-20°C

• Molecular Weight:

  44 kDa

• Fragment:

  IgG

• Specificity:

  The antibody is a rabbit polyclonal antibody raised against LYAR. It has been selected for its ability to recognize LYAR in immunohistochemical staining and western blotting.

• NCBI Gene Symbol:

  Lyar

• Host or Source:

  Rabbit

• Protein Name:

  Cell growth-regulating nucleolar protein

• Gene Name URL:

  Lyar

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_025281