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KEAP1 Antibody

CAT: 0247-OACD04962-1MLSize: 1 mLDry Ice: NoHazardous: No
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CAT#:0247-OACD04962-1MLSize:1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Kelch-like ECH-associated protein 1
Gene Aliases
Cytosolic inhibitor of Nrf2; IN; INRF2; kelch-like ECH-associated protein 1; mKIAA0132; NRF2 cytosolic inhibitor; ring canal protein.
Gene ID
50868
Accession Number
NP_001103775.1
Reactivity
Human|Mouse|Rat
Immunogen
Recombinant KEAP1 (Met1~Gln286) expressed in E.coli
Target
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against KEAP1. It has been selected for its ability to recognize KEAP1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Keap1
Host or Source
Rabbit
Protein Name
Kelch-like ECH-associated protein 1
Gene Name URL
Keap1
Nucleotide Accession Number
NM_001110305

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