CD300LF Antibody

• Gene Name:

  CD300 molecule like family member F

• Gene Aliases:

  CD300 antigen like family member F; CD300 antigen-like family member F; CLIM1; CLM1; CLM-1; CMRF35-like molecule 1; CMRF-35-like molecule 1; DC-derived Ig-like receptor 2; DIg; Digr2; F730004D16Rik; IgSF; IgSF13; IRE; IREM1; leukocyte mono-Ig-like receptor 3; LM; LMIR3; MAIR-5; MAIR-V; myeloid-associated immunoglobulin-like receptor 5; Pi; Pigr3.

• Gene ID:

  246746

• Accession Number:

  NP_001162624.1

• Reactivity:

  Human|Mouse

• Immunogen:

  Recombinant CD300LF (Ser45 - Ile310) expressed in E.coli.

• Target:

  Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:17438331) . Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells (PubMed:21865548) . Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (PubMed:26768664) . Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide which acts as a ligand (PubMed:23123064) . May act as a coreceptor for interleukin 4 (IL-4) . Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (PubMed:26124135) . Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity) . Inhibits osteoclast formation (PubMed:14662855) . Induces macrophage cell death upon engagement (PubMed:18097021) .

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

• Purification:

  Affinity Purified; Protein A Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

• Reconstitution:

  2°C to 8°C|-20°C

• Fragment:

  IgG

• Specificity:

  The antibody is a rabbit polyclonal antibody raised against IREM1. It has been selected for its ability to recognize IREM1 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol:

  Cd300lf

• Host or Source:

  Rabbit

• Protein Name:

  CMRF35-like molecule 1

• Gene Name URL:

  Cd300lf

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001169153