CASP1 Antibody

• Gene Name:

  Caspase 1, apoptosis-related cysteine peptidase

• Gene Aliases:

  CASP-1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) ; caspase-1; ICE; IL-1 beta-converting enzyme; IL-1BC; interleukin-1 beta convertase; interleukin-1 beta converting enzyme; Interleukin-1 beta-converting enzyme; p45.

• Gene ID:

  397319

• Accession Number:

  NP_999327.1

• Reactivity:

  Human|Porcine

• Immunogen:

  Recombinant CASP1 (Asn120~Asp297) expressed in E.coli

• Target:

  Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs) . Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive.

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Source:

  Polyclonal antibody preparation

• Applications:

  Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Western blot

• Purification:

  Affinity Purified; Protein A Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Format:

  Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

• Reconstitution:

  2°C to 8°C|-20°C

• Fragment:

  IgG

• Specificity:

  The antibody is a rabbit polyclonal antibody raised against CASP1. It has been selected for its ability to recognize CASP1 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol:

  CASP1

• Host or Source:

  Rabbit

• Protein Name:

  Caspase-1

• Gene Name URL:

  CASP1

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_214162