Icariin

• Description:

  Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.

• Product Name Alternative:

  Ieariline

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Autophagy; Phosphodiesterase (PDE) ; PPAR

• Type:

  Natural Products

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Icariin.html

• Purity:

  99.06

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=C(C/C=C(C)/C)C(OC(C3=CC=C(OC)C=C3)=C(O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)C5=O)=C5C(O)=C2)[C@@H]1O

• Molecular Formula:

  C33H40O15

• Molecular Weight:

  676.66

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Xin ZC, et al. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar;5 (1) :15-8.|[2]Lu YF, et al. Icariin is a PPARα activator inducing lipid metabolic gene expression in mice. Molecules. 2014 Nov 6;19 (11) :18179-91.|[3]Hu Y, et al. Effects and mechanisms of icariin on atherosclerosis. Int J Clin Exp Med. 2015 Mar 15;8 (3) :3585-9.|[4]Chen M, et al. Effects of icariin on reproductive functions in male rats. Molecules. 2014 Jul 3;19 (7) :9502-14.|[5]Liu D, et al. Icariin protects rabbit BMSCs against OGD-induced apoptosis by inhibiting ERs-mediated autophagy via MAPK signaling pathway. Life Sci. 2020 Apr 26:117730.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 3

• Isoform:

  PDE4; PDE5; PPARα

• CAS Number:

  489-32-7