LRP2 Antibody

• Gene Name:

  LDL receptor related protein 2

• Gene Aliases:

  Calcium sensor protein; DBS; glycoprotein 330; GP330; Heymann nephritis antigen homolog; low-density lipoprotein receptor-related protein 2; LRP-2; megalin.

• Gene ID:

  4036

• Reactivity:

  Human

• Immunogen:

  Range: Gly4035 - Leu4184

• Target:

  Multiligand endocytic receptor (By similarity) . Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity) . Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity) . In the kidney, mediates the tubular uptake and clearance of leptin (By similarity) . Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity) . Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity) . Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity) . Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity) . Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248) . Together with CUBN, mediates renal reabsorption of myoglobin (By similarity) . Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity) . Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity) . Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075) . Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity) . Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity) . Also mediates ShhN transcytosis (By similarity) . In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity) . Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity) . During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity) . In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity) . In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity) . Involved in neurite branching (By similarity) . During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity) . Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity) . Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity) . Mediates endocytosis of angiotensin-2 (By similarity) . Also mediates endocytosis of angiotensis 1-7 (By similarity) . Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity) . Required for embryonic heart development (By similarity) . Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity) .

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

• Purification:

  Affinity Purified; Protein A Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

• Reconstitution:

  2°C to 8°C|-20°C

• Molecular Weight:

  522 kDa

• Fragment:

  IgG

• Specificity:

  The antibody is a rabbit polyclonal antibody raised against LRP2. It has been selected for its ability to recognize LRP2 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol:

  LRP2

• Host or Source:

  Rabbit

• Protein Name:

  Low-density lipoprotein receptor-related protein 2

• Gene Name URL:

  LRP2

• CAS Number:

  9007-83-4