ERLIN2 Antibody

• Gene Name:

  ER lipid raft associated 2

• Gene Aliases:

  C8orf2; endoplasmic reticulum lipid raft-associated protein 2; epididymis secretory sperm binding protein; erlin-2; NET32; spastic paraplegia 18 (autosomal dominant) ; SPFH domain family, member 2; SPFH2; SPG18; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2.

• Gene ID:

  11160

• Accession Number:

  NP_001003790.1

• Reactivity:

  Human|Mouse|Porcine|Rat

• Immunogen:

  Range: Pro47 - Asn339

• Target:

  Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376) . Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306) . Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618) .

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

• Purification:

  Affinity Purified; Protein A Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Format:

  Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

• Reconstitution:

  2°C to 8°C|-20°C

• Molecular Weight:

  17 kDa

• Fragment:

  IgG

• Specificity:

  The antibody is a rabbit polyclonal antibody raised against ERLIN2. It has been selected for its ability to recognize ERLIN2 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol:

  ERLIN2

• Host or Source:

  Rabbit

• Protein Name:

  Erlin-2

• Gene Name URL:

  ERLIN2

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001003790