DMPK Antibody

CAT: 0247-OACD00918-100ULSize: 100 µLDry Ice: NoHazardous: No
CAT#:0247-OACD00918-100ULSize:100 µL
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CAS Number
9007-83-4
Gene Name
DM1 protein kinase
Gene Aliases
DM; DM protein kinase; DM1; DM1 protein kinase; DM1PK; DMK; DM-kinase; DMPK; dystrophia myotonica protein kinase; MDPK; MT-PK; myotonic dystrophy associated protein kinase; Myotonic dystrophy protein kinase; myotonin protein kinase A; myotonin-protein kinase; thymopoietin homolog.
Gene ID
1760
Accession Number
NP_001075029.1
Reactivity
Human|Mouse|Porcine|Rat
Immunogen
Range: Met1 - Ile201
Target
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
59 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against DMPK. It has been selected for its ability to recognize DMPK in immunohistochemical staining and western blotting.
NCBI Gene Symbol
DMPK
Host or Source
Rabbit
Protein Name
Myotonin-protein kinase
Gene Name URL
DMPK
Nucleotide Accession Number
NM_001081560

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