ERI1 Antibody

• Gene Name:

  Exoribonuclease 1

• Gene Aliases:

  3110010F15Rik;3'-5' exonuclease ERI1;3'-5' exoribonuclease 1;3'hexo; enhanced RNAi protein 1; Er; eri-1; eri-1 homolog; histone mRNA 3' end-specific exonuclease; histone mRNA 3'-exonuclease 1; Thex1; three prime histone mRNA exonuclease 1.

• Gene ID:

  67276

• Accession Number:

  NP_080343.4

• Reactivity:

  Mouse|Rat

• Immunogen:

  Range: Met1 - Lys345

• Target:

  RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) . Binds with high affinity to the 3' side of the stem-loop structure and to the downstream cleavage product (DCP) of histone pre-mRNAs. Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs (By similarity) . Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA.

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

• Purification:

  Affinity Purified; Protein A Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Format:

  Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

• Reconstitution:

  2°C to 8°C|-20°C

• Molecular Weight:

  39 kDa

• Fragment:

  IgG

• Specificity:

  The antibody is a rabbit polyclonal antibody raised against ERI1. It has been selected for its ability to recognize ERI1 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol:

  Eri1

• Host or Source:

  Rabbit

• Protein Name:

  3'-5' exoribonuclease 1

• Gene Name URL:

  Eri1

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_026067