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PTPRN2 Antibody

CAT: 0247-OACD00465-100ULSize: 100 µLDry Ice: NoHazardous: No
CAT#:0247-OACD00465-100ULSize:100 µL
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CAS Number
9007-83-4
Gene Name
Protein tyrosine phosphatase, receptor type, N polypeptide 2
Gene Aliases
4930425H11Rik; IA-2 beta; IA-2b; IA2beta; mKIAA0387; ph; phogrin; Phol; protein tyrosine phosphatase-NP; PT; PTP IA-2beta; PTP-NP; receptor-type tyrosine-protein phosphatase N2; R-PTP-N2.
Gene ID
19276
Accession Number
NP_035345.2
Reactivity
Mouse|Rat
Immunogen
Range: Gly782 - Gln1001
Target
Plays a role in vesicle-mediated secretory processes (PubMed:21732083) . Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083) . Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083) . Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463) . Required to maintain normal levels of renin expression and renin release (PubMed:19019914) . May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328) . Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI (4,5) P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity) . Regulates PI (4,5) P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI (4,5) P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
111 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PTPRN2. It has been selected for its ability to recognize PTPRN2 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Ptprn2
Host or Source
Rabbit
Protein Name
Receptor-type tyrosine-protein phosphatase N2
Gene Name URL
Ptprn2
Nucleotide Accession Number
NM_011215

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