PARG Antibody

CAT: 0247-OACA10603-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0247-OACA10603-100UGSize:100 µg
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CAS Number
9007-83-4
Gene Name
Biphenyl hydrolase like|poly (ADP-ribose) glycohydrolase
Gene Aliases
Biphenyl hydrolase-like (serine hydrolase) ; biphenyl hydrolase-related protein; BPH-RP; breast epithelial mucin-associated antigen; MCNAA; mitochondrial poly (ADP-ribose) glycohydrolase; PARG99; poly (ADP-ribose) glycohydrolase; VACVASE; valacyclovir hydrolase; valacyclovirase.
Gene ID
670|8505
Accession Number
NP_001289706
Reactivity
Human
Immunogen
Recombinant Human Poly (ADP-ribose) glycohydrolase protein (1-348AA)
Target
Poly (ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly (ADP-ribose) glycohydrolase (PubMed:23102699) . PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699) . Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699) . Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257) . Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
BPHL|PARG
Host or Source
Rabbit
Protein Name
Poly (ADP-ribose) glycohydrolase
Gene Name URL
BPHL|PARG
Nucleotide Accession Number
NM_001302777

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