PARG Antibody

• Gene Name:

  Biphenyl hydrolase like|poly (ADP-ribose) glycohydrolase

• Gene Aliases:

  Biphenyl hydrolase-like (serine hydrolase) ; biphenyl hydrolase-related protein; BPH-RP; breast epithelial mucin-associated antigen; MCNAA; mitochondrial poly (ADP-ribose) glycohydrolase; PARG99; poly (ADP-ribose) glycohydrolase; VACVASE; valacyclovir hydrolase; valacyclovirase.

• Gene ID:

  670|8505

• Accession Number:

  NP_001289706

• Reactivity:

  Human

• Immunogen:

  Recombinant Human Poly (ADP-ribose) glycohydrolase protein (1-348AA)

• Target:

  Poly (ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly (ADP-ribose) glycohydrolase (PubMed:23102699) . PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699) . Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699) . Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257) . Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence

• Purification:

  Protein G Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  BPHL|PARG

• Host or Source:

  Rabbit

• Protein Name:

  Poly (ADP-ribose) glycohydrolase

• Gene Name URL:

  BPHL|PARG

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001302777