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SCIN Antibody

CAT: 0247-OACA10181-50UGSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0247-OACA10181-50UGSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Scinderin
Gene Aliases
Adseverin; Scinderin.
Gene ID
85477
Accession Number
NP_001106177
Reactivity
Human|Mouse
Immunogen
Recombinant Human Adseverin protein (556-703AA)
Target
Ca (2+) -dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202) . Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity) . In vitro, also has barbed end capping and nucleating activities in the presence of Ca (2+) . Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009) . Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity) . Regulates chondrocyte proliferation and differentiation (By similarity) . Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Western blot
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
SCIN
Host or Source
Rabbit
Protein Name
Adseverin
Gene Name URL
SCIN
Nucleotide Accession Number
NM_001112706

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