CHTOP Antibody

• Gene Name:

  Chromatin target of PRMT1

• Gene Aliases:

  C10orf77; C1orf77; chromatin target of PRMT1 protein; FL-SRAG; FOP; friend of PRMT1 protein; pp7704; Small arginine- and glycine-rich protein; small protein rich in arginine and glycine; SRAG; SRAG-3; SRAG-5.

• Gene ID:

  26097

• Accession Number:

  NP_001193541

• Reactivity:

  Human|Mouse

• Immunogen:

  Recombinant Human Chromatin target of PRMT1 protein (179-248AA)

• Target:

  Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291) . May play a role in the silencing of fetal globin genes (PubMed:20688955) . Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity) . Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot

• Purification:

  Protein G Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  CHTOP

• Host or Source:

  Rabbit

• Protein Name:

  Chromatin target of PRMT1 protein

• Gene Name URL:

  CHTOP

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001206612