ISPD Antibody

• Gene Name:

  CDP-L-ribitol pyrophosphorylase A

• Gene Aliases:

  2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein;4-diphosphocytidyl-2C-methyl-D-erythritol synthase homolog; D-ribitol-5-phosphate cytidylyltransferase; hISPD; isoprenoid synthase domain containing; Isoprenoid synthase domain-containing protein; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip; notch1-induced protein; testicular tissue protein Li 97.

• Gene ID:

  729920

• Accession Number:

  NP_001094887

• Reactivity:

  Human

• Immunogen:

  Recombinant Human Isoprenoid synthase domain-containing protein (1-264AA)

• Target:

  Cytidylyltransferase required for protein O-linked mannosylation (PubMed:26687144, PubMed:27130732, PubMed:27601598, PubMed:22522420, PubMed:22522421) . Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:26687144, PubMed:27130732) . CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-) mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:26687144, PubMed:27130732) . Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144) . Not Involved in dolichol production (PubMed:26687144) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry

• Purification:

  Protein G Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  CRPPA

• Host or Source:

  Rabbit

• Protein Name:

  D-ribitol-5-phosphate cytidylyltransferase

• Gene Name URL:

  CRPPA

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001101417