STAT3 Antibody

• Gene Name:

  Signal transducer and activator of transcription 3

• Gene Aliases:

  Acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; HIES; signal transducer and activator of transcription 3.

• Gene ID:

  6774

• Accession Number:

  NP_003141

• Reactivity:

  Human

• Immunogen:

  Recombinant Human Signal transducer and activator of transcription 3 protein (50-240AA)

• Target:

  Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476) . Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214) . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986) . Binds to the interleukin-6 (IL-6) -responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225) . Activated by IL31 through IL31RA (PubMed:15194700) . Acts as a regulator of inflammatory response by regulating differentiation of naive CD4 (+) T-cells into T-helper Th17 or regulatory T-cells (Treg) : deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600) . Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214) . Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity) . May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580) . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476) . Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunoprecipitation

• Purification:

  Protein G Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  STAT3

• Host or Source:

  Rabbit

• Protein Name:

  Signal transducer and activator of transcription 3

• Gene Name URL:

  STAT3

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_003150