VPS11 Antibody

• Gene Name:

  VPS11 core subunit of CORVET and HOPS complexes

• Gene Aliases:

  END1; HLD12; hVPS11; PEP5; RING finger protein 108; RNF108; vacuolar protein sorting 11 homolog; vacuolar protein sorting-associated protein 11 homolog; VPS11, CORVET/HOPS core subunit.

• Gene ID:

  55823

• Accession Number:

  NP_001277114

• Reactivity:

  Human

• Immunogen:

  Recombinant Human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)

• Target:

  Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203) . Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203) . Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287) . Involved in the retrograde Shiga toxin transport (PubMed:23593995) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunohistochemistry

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  VPS11

• Host or Source:

  Rabbit

• Protein Name:

  Vacuolar protein sorting-associated protein 11 homolog

• Gene Name URL:

  VPS11

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001290185