APBB1 Antibody

• Gene Name :

  Amyloid beta precursor protein binding family B member 1

• Gene Aliases :

  Adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) ; amyloid-beta A4 precursor protein-binding family B member 1; FE65; MGC:9072; Protein Fe65; RIR; stat-like protein.

• Gene ID :

  322

• Accession Number :

  NP_001155

• Reactivity :

  Human

• Immunogen :

  Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA)

• Target :

  Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs) . Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site (s) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  Enzyme-linked immunosorbent assay|Immunohistochemistry

• Purification :

  Affinity Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format :

  Liquid

• Reconstitution :

  -20°C or -80°C

• Fragment :

  IgG

• NCBI Gene Symbol :

  APBB1

• Host or Source :

  Rabbit

• Protein Name :

  Amyloid-beta A4 precursor protein-binding family B member 1

• Gene Name URL :

  APBB1

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001164