Products for Research Use Only
RegisterLogin

BLK Antibody

CAT: 0247-OACA07128-50ULSize: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OACA07128-50ULSize:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Name
BLK proto-oncogene, Src family tyrosine kinase
Gene Aliases
B lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase; MODY11; p55-Blk; tyrosine-protein kinase Blk.
Gene ID
640
Accession Number
NP_001706
Reactivity
Human
Immunogen
Recombinant Human Tyrosine-protein kinase Blk protein (1-280AA)
Target
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR) -mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
BLK
Host or Source
Rabbit
Protein Name
Tyrosine-protein kinase Blk
Gene Name URL
BLK
Nucleotide Accession Number
NM_001715

Related Products

CatalogName
AAP46061-100UGBLK Peptide (AAP46061)
OPCD01647-50UGBLK Recombinant Protein
OPCD01647-200UGBLK Recombinant Protein
OPCD01647-10UGBLK Recombinant Protein
OKCD00423-96WBLK ELISA Kit (Human)
OKCD00423BLK ELISA Kit (Human) (OKCD00423)
OKDD00150BLK ELISA Kit (Human) (OKDD00150)
AAP73772-100UGBLK Peptide - N-terminal region (AAP73772)
OACD01074-100ULWAS Antibody
OAMA00822-1MGWAS Antibody

Alternative Products

CatalogName
MBS8529199-01H2B Antibody Antibody
MBS8513599-01CD11b Antibody Antibody
DF8746-01ASAP1 antibody Antibody
MBS850197-01Antibody to IGFBP2 Antibody
E36403ZNF98 Antibody Antibody
GWB-250026Lck antibody Antibody
E8M1007-4HSP60 Antibody Antibody
MBS9403836-01SZT2 Antibody Antibody
LSMab09882anti-Antibody^Polyclonal antibody control antibody
GWB-5C6547MAD1L1 antibody [9B10] Antibody

Popular Products