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ALKBH8 Antibody

CAT: 0247-OACA06810-50ULSize: 50 µLDry Ice: NoHazardous: No
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CAT#:0247-OACA06810-50ULSize:50 µL
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CAS Number
9007-83-4
Gene Name
AlkB homolog 8, tRNA methyltransferase
Gene Aliases
ABH8; AlkB homologue 8; alkB, alkylation repair homolog 8; alkylated DNA repair protein alkB homolog 8; MRT71; probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; TRM9; TRMT9; TRMT9A; tRNA (carboxymethyluridine (34) -5-O) -methyltransferase ABH8; tRNA methyltransferase 9 homolog; tRNA methyltransferase 9 related.
Gene ID
91801
Accession Number
NP_001287939
Reactivity
Human
Immunogen
Recombinant Human Alkylated DNA repair protein alkB homolog 8 protein (1-230AA)
Target
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323) . Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323) . Has a preference for tRNA (Arg) and tRNA (Glu), and does not bind tRNA (Lys) (PubMed:20308323) . Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5- (S) -methoxycarbonylhydroxymethyluridine; has a preference for tRNA (Gly) (PubMed:21285950) . Required for normal survival after DNA damage (PubMed:20308323) . May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
ALKBH8
Host or Source
Rabbit
Protein Name
Alkylated DNA repair protein alkB homolog 8
Gene Name URL
ALKBH8
Nucleotide Accession Number
NM_001301010

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