ENPP2 Antibody

• Gene Name:

  Ectonucleotide pyrophosphatase/phosphodiesterase 2

• Gene Aliases:

  ATX; ATX-X; AUTOTAXIN; autotaxin-t; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; extracellular lysophospholipase D; LysoPLD; NPP2; PD-IALPHA; PDNP2; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D.

• Gene ID:

  5168

• Accession Number:

  NP_001035181

• Reactivity:

  Human

• Immunogen:

  Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 protein (564-863AA)

• Target:

  Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931) . Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931) . Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993) . Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573) . Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949) . May have a role in induction of parturition (PubMed:12176993) . Possible involvement in cell proliferation and adipose tissue development (Probable) . Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunohistochemistry

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  ENPP2

• Host or Source:

  Rabbit

• Protein Name:

  Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

• Gene Name URL:

  ENPP2

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001040092