RNF138 Antibody

CAT: 0247-OACA05798-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0247-OACA05798-100UGSize:100 µg
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CAS Number
9007-83-4
Gene Name
Ring finger protein 138
Gene Aliases
E3 ubiquitin-protein ligase RNF138; hNARF; HSD-4; NARF; nemo-like kinase associated ring finger protein; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein; RING finger protein 138; ring finger protein 138, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF138; STRIN; testicular tissue protein Li 165.
Gene ID
51444
Accession Number
NP_001178253
Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase RNF138 protein (2-245AA)
Target
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057) . Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057) . Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ) : acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055) . According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057) . Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285) . Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285) . May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
RNF138
Host or Source
Rabbit
Protein Name
E3 ubiquitin-protein ligase RNF138
Gene Name URL
RNF138
Nucleotide Accession Number
NM_001191324

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