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KDM8 Antibody

CAT: 0247-OACA05556-50UGSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0247-OACA05556-50UGSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Lysine demethylase 8
Gene Aliases
Arginyl C3-hydroxylase KDM8; bifunctional peptidase and arginyl-hydroxylase JMJD5; JmjC arginyl-hydroxylase; jmjC domain-containing protein 5; JMJD5; jumonji C domain-containing protein 5; jumonji domain containing 5; jumonji domain-containing protein 5; L-arginine (3R) -hydroxylase KDM8; lysine (K) -specific demethylase 8; lysine-specific demethylase 8.
Gene ID
79831
Accession Number
NP_001138820
Reactivity
Human
Immunogen
Recombinant Human JmjC domain-containing protein 5 protein (151-380AA)
Target
Histone demethylase required for G2/M phase cell cycle progression (PubMed:20457893) . Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (PubMed:20457893) . Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation (PubMed:20457893) . In a complex with coregulator RCCD1, is also able to demethylate trimethylated 'Lys-36' (H3K36me3) of histone H3 (PubMed:24981860) . Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1 (PubMed:24981860) . Possibly together with RCCD1, involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860) . Plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability (PubMed:28455245) . Might function as a protein hydroxylase (PubMed:22851697, PubMed:24100311) . Under stress conditions that cause a DNA damage response, acts as a histone protease by cleaving the N-terminal tail of histone H3 at the carboxyl side of monomethyl-lysine (Kme1) residues, preferably at monomethylated 'Lys-9' (H3K9me1) (PubMed:28982940) . The histone variant H3F3A is the major target for cleavage (PubMed:28982940) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
KDM8
Host or Source
Rabbit
Protein Name
JmjC domain-containing protein 5
Gene Name URL
KDM8
Nucleotide Accession Number
NM_001145348

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