SETX Antibody

CAT: 0247-OACA05235-50UGSize: 50 µgDry Ice: NoHazardous: No
CAT#:0247-OACA05235-50UGSize:50 µg
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CAS Number
9007-83-4
Gene Name
Senataxin
Gene Aliases
ALS4; amyotrophic lateral sclerosis 4 protein; AOA2; bA479K20.2; probable helicase senataxin; SCAN2; SCAR1; Sen1; SEN1 homolog; Senataxin.
Gene ID
23064
Accession Number
NP_055861
Reactivity
Human
Immunogen
Recombinant Human Probable helicase senataxin protein (2401-2677AA)
Target
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224) . Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850) . Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly (A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805) . Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity) . Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789) . In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744) . Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity) . May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256) . Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
SETX
Host or Source
Rabbit
Protein Name
Probable helicase senataxin
Gene Name URL
SETX
Nucleotide Accession Number
NM_015046

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