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UBE2V1 Antibody

CAT: 0247-OACA03908-50UGSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0247-OACA03908-50UGSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
PEDS1-UBE2V1 readthrough|ubiquitin conjugating enzyme E2 V1
Gene Aliases
CIR1; CROC1; CROC-1; CROC1B; CROC-1B; DNA-binding protein; KUA-UEV; TMEM189-UBE2V1; TMEM189-UBE2V1 fusion protein; TMEM189-UBE2V1 readthrough transcript; TRAF6-regulated IKK activator 1 beta Uev1A; transmembrane protein 189-ubiquitin-conjugating enzyme E2 variant 1 read-through; UBE2V; ubiquitin-conjugating enzyme E2 variant 1; UEV1; UEV-1; UEV1A.
Gene ID
387522|7335
Accession Number
NP_001027459
Reactivity
Human
Immunogen
Recombinant Human Ubiquitin-conjugating enzyme E2 variant 1 protein (2-147AA)
Target
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
PEDS1-UBE2V1|UBE2V1
Host or Source
Rabbit
Protein Name
Ubiquitin-conjugating enzyme E2 variant 1
Gene Name URL
PEDS1-UBE2V1|UBE2V1
Nucleotide Accession Number
NM_001032288

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