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PNRC2 Antibody

CAT: 0247-OACA03466-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OACA03466-100UGSize:100 µg
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CAS Number
9007-83-4
Gene Name
Proline rich nuclear receptor coactivator 2
Gene Aliases
Proline-rich nuclear receptor coactivator 2.
Gene ID
55629
Accession Number
NP_060231
Reactivity
Human
Immunogen
Recombinant Human Proline-rich nuclear receptor coactivator 2 protein (1-139AA)
Target
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429) . May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429) . Required for UPF1/RENT1 localization to the P-body (PubMed:19150429) . Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514) . Also acts as a nuclear receptor coactivator (PubMed:11574675) . May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
PNRC2
Host or Source
Rabbit
Protein Name
Proline-rich nuclear receptor coactivator 2
Gene Name URL
PNRC2
Nucleotide Accession Number
NM_017761

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