PLA2G16 Antibody

• Gene Name:

  Phospholipase A and acyltransferase 3

• Gene Aliases:

  Adipose-specific phospholipase A2; adipose-specific PLA2; AdPLA; Ca-independent phospholipase A1/2; group XVI phospholipase A1/A2; group XVI phospholipase A2; HRAS-like suppressor 1; HRAS-like suppressor 3; HRASLS3; H-rev 107 protein homolog; HREV107; H-REV107; HREV107-1; H-REV107-1; HREV107-3; HRSL3; phospholipase A and acyltransferase 3; phospholipase A/acyltransferase-3; phospholipase A2 group XVI; PLA2G16; PLAAT-3; renal carcinoma antigen NY-REN-65.

• Gene ID:

  11145

• Accession Number:

  NP_001121675

• Reactivity:

  Human

• Immunogen:

  Recombinant Human HRAS-like suppressor 3 protein (1-132AA)

• Target:

  Lipid-modifying enzyme that acts as major regulator of adipocyte lipolysis by catalyzing the release of fatty acids from phospholipids in adipose tissue (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616) . Shows phospholipase A1 and A2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616) . For most substrates, phospholipase A1 activity is much higher than phospholipase A2 activity (PubMed:19047760) . Phospholipase activity causes decreased intracellular levels of ether-type lipids, affecting peroxisome metabolism (By similarity) . May also have acyltransferase activity: catalyzes both N-acylation of phosphatidylethanolamine to form N-acyl-phosphatidylethanolamine and O-acylation of lyso-phosphatidylcholines to form phosphatidylcholines (PubMed:22605381, PubMed:25383759) . The relevance of acyltransferase activity in vivo is however unclear and would require additional evidences (PubMed:22605381, PubMed:25383759) . Also has weak lysophospholipase activity (By similarity) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunohistochemistry

• Purification:

  Protein G Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  Varies by lot. See vial for exact concentration.

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  PLAAT3

• Host or Source:

  Rabbit

• Protein Name:

  HRAS-like suppressor 3

• Gene Name URL:

  PLAAT3

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001128203