MICAL2 Antibody

• Gene Name:

  Microtubule associated monooxygenase, calponin and LIM domain containing 2

• Gene Aliases:

  [F-actin]-methionine sulfoxide oxidase MICAL2; [F-actin]-monooxygenase MICAL2; ebitein-1; Ebitein1; ERK2-binding testicular protein 1; flavoprotein oxidoreductase MICAL2; MICAL C-terminal like; MICAL C-terminal-like protein; MICAL-2; MICAL2PV1; MICAL2PV2; mical-cL; MICALCL; microtubule associated monoxygenase, calponin and LIM domain containing 2; molecule interacting with CasL protein 2; protein-methionine sulfoxide oxidase MICAL2.

• Gene ID:

  9645

• Accession Number:

  NP_001269592

• Reactivity:

  Human

• Immunogen:

  Recombinant Human [F-actin]-monooxygenase MICAL2 protein (1-495AA)

• Target:

  Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H (2) O (2) (By similarity) . Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry

• Purification:

  Protein G Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  MICAL2

• Host or Source:

  Rabbit

• Protein Name:

  [F-actin]-monooxygenase MICAL2

• Gene Name URL:

  MICAL2

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001282663