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(-) -Latifolin

CAT: 0804-HY-N8380-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8380-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-) -Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-) -Latifolin suppresses autophagic-related proteins and autophagosome formation. (-) -Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL) . (-) -Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities[1].
CAS Number
10154-42-4
UNSPSC
12352005
Target
Apoptosis; Autophagy; Necroptosis; PI3K
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/minus-latifolin.html
Solubility
10 mM in DMSO
Smiles
OC1=CC([C@@H](C2=CC=CC=C2O)C=C)=C(OC)C=C1OC
Molecular Formula
C17H18O4
Molecular Weight
286.32
References & Citations
[1]Hyung-Mun Yun, et al. Latifolin, a Natural Flavonoid, Isolated from the Heartwood of Dalbergia odorifera Induces Bioactivities through Apoptosis, Autophagy, and Necroptosis in Human Oral Squamous Cell Carcinoma. Int J Mol Sci. 2022 Nov 7;23 (21) :13629.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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