RegisterLogin

SERCA1 Polyclonal Antibody

CAT: 0247-OABB00671-100UGSize: 100 µg/VialDry Ice: NoHazardous: No
CAT#:0247-OABB00671-100UGSize:100 µg/Vial
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
9007-83-4
Gene Name
Raf-1 proto-oncogene, serine/threonine kinase
Gene Aliases
CMD1NN; c-Raf; CRAF; C-Raf proto-oncogene, serine/threonine kinase; NS5; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1.
Gene ID
5894
Swiss Prot
P10644
Reactivity
Human
Immunogen
A synthesized peptide derived from human Phospho-RAF1 (S621)
Clonality
Recombinant Monoclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) . The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1) . Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
Format
Liquid
Reconstitution
-20°C or -80°C
NCBI Gene Symbol
RAF1
Protein Name
RAF proto-oncogene serine/threonine-protein kinase
Gene Name URL
RAF1

Related Products

CatalogName
OABB00672-100UGSERCA2 Polyclonal Antibody
ARP60700_P050-25ULSERAC1 Antibody - C-terminal region
ARP60701_P050-25ULSERAC1 Antibody - N-terminal region
ARP60700_P050SERAC1 Antibody - C-terminal region (ARP60700_P050)
ARP60701_P050SERAC1 antibody - N-terminal region (ARP60701_P050)
OABB00657-100UGSLC6A4 Polyclonal Antibody
OABB00400-100UGCXCL4 Polyclonal Antibody
OABB00303-100UGPLAUR Polyclonal Antibody
OABB00381-100UGCA1 Polyclonal Antibody
OABB00772-100UGKLK10 Polyclonal Antibody

Alternative Products

CatalogName
MBS9245192-01SERCA1 Polyclonal Antibody
BS91222SERCA1 ATPase polyclonal antibody
BS74361SERCA1/ATP2A1 polyclonal antibody
APRab17747-01SERCA1 Rabbit Polyclonal Antibody
C41428SERCA1 Polyclonal Conjugated Antibody
BS3934-01SERCA1 (D580) polyclonal antibody
E-AB-90070-01SERCA1/ATP2A1 Polyclonal Antibody
GWB-BBP594Polyclonal Anti-SERCA1 Antibody
ER1803-34ATP2A1/SERCA1 Rabbit Polyclonal Antibody
NBP3-25129Rabbit Polyclonal SERCA1 ATPase Antibody

Popular Products