Products for Research Use Only
RegisterLogin

RFWD2 Antibody

CAT: 0247-OAAN04279-200ULSize: 200 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OAAN04279-200ULSize:200 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Name
Ring finger and WD repeat domain 2
Gene Aliases
FAP78, RFWD2, CFAP78, RNF200
Gene ID
64326
Swiss Prot
Q8NHY2
Accession Number
NP_001001740.1
Reactivity
Human, Mouse
Immunogen
Recombinant Protein
Target
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity purification
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
Store at +4C. For long term storage, aliquote and store at -20C. Avoid freeze/thaw cycles.
Molecular Weight
80 kDa
Fragment
IgG
NCBI Gene Symbol
RFWD2
Host or Source
Rabbit
Protein Name
D-3-phosphoglycerate dehydrogenase
Gene Name URL
RFWD2
Nucleotide Accession Number
NM_001001740.3

Related Products

CatalogName
OPCA05343-20UGRFWD2 Recombinant Protein (Human)
OPCA05343-100UGRFWD2 Recombinant Protein (Human)
OKAG01016RFWD2 Colorimetric Cell-Based ELISA Kit (OKAG01016)
OKAG02176Phospho-RFWD2 (Ser387) Colorimetric Cell-Based ELISA Kit (OKAG02176)
OAAJ05319-100ULRFWD3 Antibody
OAAF04209-100UGRFWD3 Antibody
OAGA05368-100ULRFWD3 Antibody
OAAF07037-100UGOAAF07037-100UG - RFWD3 Antibody
OASG06351-100ULRFWD3 Antibody - middle region
OAAF04209-100UG-BiotinRFWD3 Antibody : Biotin (OAAF04209-Biotin)

Alternative Products

CatalogName
DF4023-01RFWD2 Antibody

Popular Products