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MMACHC Antibody

CAT: 0247-OAAN04232-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OAAN04232-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Metabolism of cobalamin associated C
Gene Aliases
Alkylcobalamin:glutathione S-alkyltransferase; cblC; cyanocobalamin reductase (cyanide-eliminating) ; cyanocobalamin reductase / alkylcobalamin dealkylase; methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; methylmalonic aciduria and homocystinuria type C protein.
Gene ID
25974
Swiss Prot
Q9Y4U1
Accession Number
NP_001317469.1
Reactivity
Human, Mouse, Rat
Immunogen
MMACHC
Target
Catalyzes the reductive dealkylation of cyanocobalamin to cob (II) alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810) . Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485) . Under anaerobic conditions cob (I) alamin is the first product; it is highly reactive and is converted to aquocob (II) alamin in the presence of oxygen (PubMed:19801555) . Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Western blot
Purification
Affinity purification
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
Store at +4C. For long term storage, aliquote and store at -20C. Avoid freeze/thaw cycles.
Molecular Weight
32kDa
Fragment
IgG
NCBI Gene Symbol
MMACHC
Host or Source
Rabbit
Protein Name
Methylmalonic aciduria and homocystinuria type C protein
Gene Name URL
MMACHC
Nucleotide Accession Number
NM_001330540.1

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