PDE6B Antibody

• Gene Name :

  Phosphodiesterase 6B

• Gene Aliases :

  Rd1, PDEB, RP40, CSNB3, CSNBAD2, GMP-PDEbeta

• Gene ID :

  5158

• Swiss Prot :

  P35913

• Accession Number :

  NP_000274.2

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant protein of human PDE6B

• Target :

  Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IHC

• Purification :

  Affinity purified against immunogen

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format :

  Liquid

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Reconstitution :

  Store at -20C. Avoid repeated freeze/thaw cycles.

• Molecular Weight :

  98 kDa

• Fragment :

  IgG

• NCBI Gene Symbol :

  PDE6B

• Host or Source :

  Rabbit

• Protein Name :

  Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

• Gene Name URL :

  PDE6B

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_000283.3